Laser diagnostics of the human sinuses and evaluation of heating
If you are interested in medical technology, physics, especially laser spectroscopy and handson measurements on humans, this is the perfect master thesis project for you!
The project is a collaboration between the Department of Physics, LTH and GPX Medical AB in Lund.
The method of GASMAS, GAs in Scattering Media Absorption Spectroscopy, was developed at the Department of Atomic Physics and is now applied in industry in a diverse number of applications. The technology utilizes tunable diode laser spectroscopy for gas concentration measurement. One medical application is the diagnostics of the human sinuses where the method can provide valuable information on the ventilation stage of the sinus and potentially also measure oxygen gas concentration. Resistance to antibiotics is a severe and increasing threat for humanity. A medical device assessing the ventilation stage may potentially reduce the prescription of antibiotics relating to sinusitis.
As always when working with lasers in medical applications, utmost caution is needed concerning both eye and skin safety. The lasers operate in the near-infrared region and there is a lack of information on heating effects on skin for these wavelengths. This can be assessed by a study using a heat camera and laser illumination.
This thesis project is a hands-on project to perform two different measurement campaigns on healthy volunteers:
- Design and perform a study measuring oxygen and water vapor gas concentrations of the sinuses for some different source-detector configurations.
- Design and perform a heating study to assess the temperature increase versus laser power on skin and also inside the mouth.
Does this seem interesting? Please do not hesitate to contact either Nina Reistad at the Department of Physics, firstname.lastname@example.org, 046 222 34 74 or Sara Bergsten at GPX Medical AB, email@example.com, 0765 25 79 96.
This project could start earliest January 2019
Tissue characterization using diffuse reflectance- and time-of-flight spectroscopy
Optical techniques have a great potential as diagnostic tools in the medical field. The Atomic Physics Division has a long tradition in interdisciplinary research pursued together with medical researchers. The present diploma project concerns the further development and application of advanced equipment available at the division, and participation in data recordings from patients at the Surgery and/or Eye clinics of Lund University Hospital. The work further includes development of efficient methods for data handling and extraction of parameters of clinical importance, e.g. tissue oxygenation.
Biomedical application of gas in scattering media absorption spectroscopy (GASMAS)
GASMAS is a novel high-resolution laser spectroscopic technique with important applications in the field of biophotonics. Ongoing projects, pursued in an interdisciplinary collaboration, include measurements of oxygenation in the lungs of new-born babies, diagnostics of inner-ear infection, and assessment of the viability in bones after fracture. The Atomic Physics Division collaborates with several departments at Lund University, the Applied Laser Spectroscopy Group at South China Normal University (SCNU) in Guangzhou, China, which is associated to Lund, and the Lund company GPX Medical. The work involves further development of existing advanced equipment, and its clinical application after functionality tests on tissue phantom samples. Part of the work may be performed at SCNU, Guangzhou.
For more information: Contact Prof. Sune Svanberg, Atomic Physics Division firstname.lastname@example.org, Prof. Katarina Svanberg, email@example.com or Doc. Nina Reistad, firstname.lastname@example.org.