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Atomic Physics

Faculty of Engineering, LTH

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Fluorescence diagnostics

Our research on fluorescence spectroscopy and imaging mainly concerns biomedical diagnostics and biological research. We are presently involved in an EU project called BRIGHTER.  In this project we develop novel instruments for in vivo diagnostics based on tissue autofluorescence imaging. Novel excitation lasers are developed.

In another project call NeuroTech (Neuro-engineering for navigation, intervention and implementation in neurosurgery) with Karin Wårdell at Department of Biomedical Engineering at Linköping University as a coordinator, we develop instruments for fluorescence guidance in connection to surgical brain tumour resections. This project is supported by the Swedish Foundation for Strategic Research (SSF), the Swedish Research Council (VR) and the Swedish Governmental Agency for Innovation Systems (Vinnova).

In a third fluorescence based project we develope instruments and techniques for experimental biological studies.

Publications

High power 404 nm source based on second harmonic generation in PPKTP of a tapered external feedback diode laser
J. Holm Lundeman, O. Bjarlin Jensen, P. E. Andersen, S. Andersson-Engels, B. Sumpf, G. Erbert, and P. M. Petersen
Optics Express 16, 2486-2493 (2008)

Fluorescence monitoring of a topically applied liposomal temoporfin formulation and photodynamic therapy of nonpigmented skin malignancies
N. Bendsoe, L. Persson, A. Johansson, J. Axelsson, J. Svensson, S. Gräfe, T. Trebst, S. Andersson-Engels, S. Svanberg, and K. Svanberg
J. Environmenetal Pathology, Toxicology and Oncology 2, 117-126 (2007)

Fluorescence and absorption assessment of a lipid mTHPC formulation following topical application in a non-melanotic skin tumor model
A. Johansson, J. Svensson, N. Bendsoe, K. Svanberg, E. Alexandratou, M. Kyriazi, D. Yova, S. Gräfe, T. Trebst, and S. Andersson-Engels
J. Biomedical Optics 12,034026 (2007)

Tumor selectivity at short times following systemic administration of a liposomal temoporfin formulation in a murine tumor model
J. Svensson, A. Johansson, S. Grafe, B. Gitter, T. Trebst, N. Bendsoe, S. Andersson-Engels, and K. Svanberg
Photochemistry and Photobiology 83, 1211-1219 (2007)

Photobleaching behavior of protoporphyrin IX during 5-aminolevulinic acid marked glioblastoma detection
Haj-Hosseini N, Richter J, Andersson-Engels S, Wårdell K; , Proc. of SPIE Vol. 7161, 716131, 2009.

Evaluation of a fiber-optic based pulsed laser system for fluorescence spectroscopy
Haj-Hosseini N, Andersson-Engels S, Wårdell K. , NBC-IFMBE Proceedings 20, 363-366, 2008.

 


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