In certain cases of skin cancer removal skin transplants are used. Periorbiatal tumour reconstruction is very crucial and monitoring of the flap tissue blood flow, composition and function can improve the outcome of the procedure. Studies are performed in experimental pigs and in patients going through reconstructive surgery following periorbital tumor excision. If we know how the blood flow and the survival of tissue are affected by these surgical procedures, it will be easier to perform simpler and less invasive reconstructions following tumor removal. We will study and develop the use of modern non-invasive imaging techniques including Laser Speckle Contrast Imaging (LSCI), Diffuse Reflectance Spectroscopy (DRS) and Photoacoustic Imaging (PAI) in experimental pigs and in patients going through reconstructive surgery following periorbital tumor excision. Through these developments, we believe that it will be possible to optimize surgical techniques, improve the result of surgery and reduce the suffering of the patient.